The best times to apply the porexsome ReDRN Exosome Ampoule vary based on user preferences and skin type. Many reviewers suggest applying it in the evening as part of their nighttime skincare routine due to its retinol content, which can make the skin more sensitive to UV rays. This allows the skin to benefit from the ampoule's effects overnight without the risk of sun-induced irritation. However, some users also apply it in the morning, especially if they have oily or combination skin, to take advantage of its quick absorption and non-sticky finish. For those with dry skin, it's recommended to follow up with a moisturizer to ensure adequate hydration.