Based on the provided reviews, the PDRN Pink Peptide Serum by Medicube has shown mixed results for acne-prone skin. Some users with hormonal acne have reported positive results, while others experienced breakouts. It's generally recommended for dry skin but may be too rich for oily skin types. Layering with other products, like the AnuA azelaic+10 azelaic acid serum, might be possible but could lead to a heavy or sticky feeling. In hot or humid weather, the serum's rich texture might not be ideal. For PIE (post-inflammatory erythema), some users have seen improvements, while others have not. The serum may help with redness and provides some barrier support, though this varies among users. It's important to consider your specific skin type and concerns when deciding if this product is suitable for you.